2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

Base Information

Chemical Name:2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran
CAS No.:878627-99-7
Molecular Formula:C₃₀H₄₈O₃Si₂
Molecular Weight:512.88
Hs Code.:

2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

Synonyms:2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

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Chemical Property of 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

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Technology Process of 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

There total 5 articles about 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 878627-95-3
(2R,3S,6R)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-methyl-tetrahydro-pyran-3-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 878627-99-7
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.12.055

Reference yield:

: 878627-91-9
7a-methoxy-5-methyl-hexahydro-furo[3,2-b]pyran-2-one

: 878627-99-7
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / LiAlH₄; BF₃*OEt₂

2: 91 percent / imidazole / tetrahydrofuran

3: 83 percent / tetrapropylammonium perruthenate; NMO / CH₂Cl₂

4: sodium borohydride / methanol; CH₂Cl₂ / -78 °C

5: 80 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.12.055

Reference yield:

: 878627-92-0
(R)-2-(2-Hydroxy-ethyl)-6-methyl-tetrahydro-pyran-3-ol

: 878627-99-7
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-6-methyl-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / imidazole / tetrahydrofuran

2: 83 percent / tetrapropylammonium perruthenate; NMO / CH₂Cl₂

3: sodium borohydride / methanol; CH₂Cl₂ / -78 °C

4: 80 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.12.055