2-Bromo-4,6-difluoroaniline hydrobromide

Base Information

• Chemical Name: 2-Bromo-4,6-difluoroaniline hydrobromide
• CAS No.: 101471-20-9
• Molecular Formula: C6H5Br2F2N
• Molecular Weight: 288.917
• Hs Code.: 2921420090
• European Community (EC) Number: 670-365-4
• DSSTox Substance ID: DTXSID50373630
• Mol file: 101471-20-9.mol

Synonyms:2-bromo-4,6-difluoroaniline hydrobromide;101471-20-9;2-bromo-4,6-difluoroaniline;hydrobromide;2-Bromo-4,6-difluoroanilinehydrobromide;Benzenamine, 2-bromo-4,6-difluoro-, hydrobromide (1:1);Benzenamine, 2-bromo-4,6-difluoro-, hydrobromide;SCHEMBL7131565;DTXSID50373630;2-bromo-4,6-difluoroaniline HBr;AKOS015911479;FT-0642452;2-Bromo-4,6-difluoroaniline hydrobromide, tech.;A800392;Benzenamine,2-bromo-4,6-difluoro-,hydrobromide(1:1)

Chemical Property of 2-Bromo-4,6-difluoroaniline hydrobromide

Chemical Property:

• Vapor Pressure: 0.219mmHg at 25°C
• Boiling Point: 208 °C at 760 mmHg
• Flash Point: 79.6 °C
• PSA: 26.02000
• LogP: 3.84880
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 288.87363
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4,6-difluoroanilinehydrobromide,tech. 80% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1F)N)Br)F.Br

Technology Process of 2-Bromo-4,6-difluoroaniline hydrobromide

There total 1 articles about 2-Bromo-4,6-difluoroaniline hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,4-difluorophenylamine (367-25-9,76563-56-9) → 2-bromo-4,6-difluoroaniline hydrobromide (101471-20-9)

Guidance literature:

With bromine; In acetic acid; for 0.25h; Ambient temperature;

DOI:10.1021/jm00386a008

Reference yield: 75.0%

hypophosphorous acid (6303-21-5) + 2-bromo-4,6-difluoroaniline hydrobromide (101471-20-9) → 3,5-difluorobromobenzene (461-96-1)

Guidance literature:

With sodium nitrite; In hydrogenchloride;

Reference yield:

2-bromo-4,6-difluoroaniline hydrobromide (101471-20-9) → 3,5-difluorobromobenzene (461-96-1)

Guidance literature:

With sodium hypophosphite; hydrogen bromide; sodium nitrite; Yield given. Multistep reaction;

DOI:10.1021/jm00156a002

upstream raw materials:

2,4-difluorophenylamine

Downstream raw materials:

3,5-difluorobromobenzene

3,5-difluorobenzonitrile

3,5-difluorobenzaldehyde

SKF 102698

Refernces

• 1、 Kruse, Lawrence I.,Kaiser, Carl,DeWolf, Walter E.,Frazee, James S.,Erickson, Robert W.,et al.. "Substituted 1-Benzylimidazole-2-thiols as Potent and Orally Active Inhibitors of Dopamine β-Hydroxylase". . p. 887 - 889. Retrieved 2007/10/02.