[3,4-Diacetyloxy-5-(5-bromo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

Base Information

• Chemical Name: [3,4-Diacetyloxy-5-(5-bromo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
• CAS No.: 105659-32-3
• Molecular Formula: C₁₅H₁₇BrN₂O₉
• Molecular Weight: 449.212
• DSSTox Substance ID: DTXSID80400903
• Mol file: 105659-32-3.mol

Synonyms:105659-32-3;ChemDiv1_019943;Oprea1_773424;SCHEMBL21277505;HMS643K11;DTXSID80400903;[3,4-diacetyloxy-5-(5-bromo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate;EU-0001696;FT-0642605;SR-01000312939;SR-01000312939-1;4-(acetyloxy)-2-[(acetyloxy)methyl]-5-[5-bromo-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-furanyl acetate

Chemical Property of [3,4-Diacetyloxy-5-(5-bromo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

Chemical Property:

• Appearance/Colour: White Solid
• PSA: 142.99000
• Density: 1.66 g/cm³
• LogP: -0.37700
• Solubility.: Chloroform, Methanol
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 8
• Exact Mass: 448.01174
• Heavy Atom Count: 27
• Complexity: 707

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2'',3'',5''-tri-O-acetyluridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC1C(C(C(O1)N2C=C(C(=O)NC2=O)Br)OC(=O)C)OC(=O)C

Technology Process of [3,4-Diacetyloxy-5-(5-bromo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

There total 7 articles about [3,4-Diacetyloxy-5-(5-bromo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Tri-O-acetyluridine (4105-38-8) → 5-bromo-2’,3’,5’-tri-O-acetyluridine (105659-31-2,105659-32-3)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 40 ℃; for 2h;

DOI:10.1016/j.tetlet.2012.04.081

Reference yield: 95.9%

5-bromouridine (957-75-5) + acetic anhydride (108-24-7) → 5-bromo-2’,3’,5’-tri-O-acetyluridine (105659-31-2,105659-32-3)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1002/anie.201001242

Reference yield: 93.0%

2,4-bis-(trimethylsilyloxy)-5-bromopyrimidine (33282-64-3) + 1,2,3,5-tetraacetylribose (13035-61-5) → 5-bromo-2’,3’,5’-tri-O-acetyluridine (105659-31-2,105659-32-3)

Guidance literature:

With poly(4,5-diphenyl-2-vinyloxazolium perchlorate); In acetonitrile; for 6h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2017.03.046

upstream raw materials:

Tri-O-acetyluridine

5-bromouridine

acetic anhydride

5-bromouracil

Downstream raw materials:

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

5-bromouridine

5-bromo-N3-benzoyl-2’,3’,5’-tri-O-acetyluridine

N₃-benzoyl-2',3',5'-O-triacetoxyuridine-5-malonic acid dimethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 105659-32-3 5-BROMO-2',3',5'-TRI-O-ACETYLURIDINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send