methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate

Base Information

• Chemical Name: methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate
• CAS No.: 74614-98-5
• Molecular Formula: C₂₄H₂₅NO₆
• Molecular Weight: 423.466
• Mol file: 74614-98-5.mol

Synonyms:methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate

Chemical Property of methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate

There total 10 articles about methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-97-4) → methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate (74614-98-5)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Ambient temperature;

DOI:10.1021/ja00366a028

Reference yield:

methyl 4-<3,4-dimethoxy-2-(9phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide → methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate (74614-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 2 h / 120 °C

2: 100 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

With potassium carbonate; In methanol;

DOI:10.1021/ja00366a028

Reference yield:

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate (74614-94-1) → methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate (74614-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 93 percent / 2 h / 120 °C

3: 100 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1021/ja00366a028

upstream raw materials:

methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate

3,4-dimethoxy-(phenylmethoxy)benzaldehyde

<3,4-dimethoxy-2-(phenylmethoxy)phenyl>oxirane

Downstream raw materials:

methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

methyl 4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-5-formyl-3,6-dimethyl-2-pyridinecarboxylate

methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-formyl-3-methyl-2-pyridinecarboxylate

methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate