(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

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Chemical Name:(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester
CAS No.:1445563-89-2
Molecular Formula:C₃₂H₃₇F₃N₆O₉S₂
Molecular Weight:770.808
Hs Code.:

(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

Synonyms:(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

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Chemical Property of (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

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Technology Process of (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

There total 16 articles about (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 40510-86-9
chloromethyl cyclohexyl carbonate

: (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid hydrochloride

: 1445563-89-2
(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: (2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid propyl ester hydrochloride

: 1445563-89-2
(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 4 h / 80 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; potassium iodide; In water; N,N-dimethyl-formamide;

Reference yield:

: 659-28-9
p-trifluoromethoxybenzaldehyde

: 1445563-89-2
(2R)-3-(1-amino-7-trifluoromethoxyisoquinolin-6-yl)-2-[(3S)-2-oxo-3-[(2-pyrrolidin-1-ylthiazole-5-sulfonyl)amino]pyrrolidin-1-yl]propionic acid cyclohexyloxycarbonyloxymethyl ester

Guidance literature:: Multi-step reaction with 15 steps

1.1: N-Bromosuccinimide; sulfuric acid / dichloromethane; trifluoroacetic acid / 48 h / 20 °C

2.1: pyridine; piperidine / 2 h / 100 °C

3.1: triethylamine; chloroformic acid ethyl ester / acetone / 1 h / 0 °C

3.2: 1 h / 0 °C

4.1: tributyl-amine / diphenylether / 250 °C / Inert atmosphere

5.1: trichlorophosphate / toluene / 1 h / Reflux

6.1: potassium carbonate; acetamide / water; ethyl acetate / 1 h / 180 °C

7.1: triethylamine / N,N-dimethyl-formamide / 15 h / 50 °C

8.1: tetraethylammonium chloride; sodium hydrogencarbonate; palladium diacetate / N,N-dimethyl-formamide / 2 h / 95 °C

9.1: {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate; hydrogen / methanol / 15 h / 20 °C / 3750.38 Torr / Inert atmosphere; Autoclave

10.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

12.1: titanium(IV) isopropylate / 2 h / Reflux

13.1: hydrogenchloride / water; acetonitrile

14.1: hydrogenchloride / water / 4 h / 80 °C

15.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With piperidine; pyridine; acetamide; titanium(IV) isopropylate; hydrogenchloride; N-Bromosuccinimide; {(-)-1,2-bis(2R,5R)-2,5-dimethylphospholanobenzene(cyclooctadiene)rhodium(l)} triflate; tributyl-amine; sulfuric acid; tetraethylammonium chloride; hydrogen; palladium diacetate; chloroformic acid ethyl ester; sodium hydrogencarbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; trichlorophosphate; In methanol; diphenylether; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; trifluoroacetic acid;