Technology Process of C51H64O8
There total 6 articles about C51H64O8 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C20H24O5;
With
2,4,6-trichlorobenzoyl chloride; triethylamine;
In
toluene;
at 20 ℃;
for 3h;
C31H42O4;
With
dmap;
In
toluene;
at 50 ℃;
for 1.5h;
DOI:10.1016/j.tet.2013.02.008
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C
1.2: 2.5 h / 0 - 20 °C
2.1: magnesium bromide ethyl etherate / dichloromethane / 1 h / -78 °C
2.2: 1.5 h / -78 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 21.5 h / 0 - 20 °C
4.1: sodium hydrogencarbonate; methyl iodide / acetonitrile; water / 19 h / 20 °C
5.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / tetrahydrofuran; water; tert-butyl alcohol / 0.5 h / 4 °C
6.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 3 h / 20 °C
6.2: 1.5 h / 50 °C
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; magnesium bromide ethyl etherate; triethylamine; methyl iodide;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; mineral oil; tert-butyl alcohol;
2.2: |Grignard Reaction / 6.1: |Yamaguchi Lactonization / 6.2: |Yamaguchi Lactonization;
DOI:10.1016/j.tet.2013.02.008
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 21.5 h / 0 - 20 °C
2.1: sodium hydrogencarbonate; methyl iodide / acetonitrile; water / 19 h / 20 °C
3.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / tetrahydrofuran; water; tert-butyl alcohol / 0.5 h / 4 °C
4.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / toluene / 3 h / 20 °C
4.2: 1.5 h / 50 °C
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; sodium hydride; sodium hydrogencarbonate; triethylamine; methyl iodide;
In
tetrahydrofuran; water; toluene; acetonitrile; mineral oil; tert-butyl alcohol;
4.1: |Yamaguchi Lactonization / 4.2: |Yamaguchi Lactonization;
DOI:10.1016/j.tet.2013.02.008
