7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine

Base Information

• Chemical Name: 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine
• CAS No.: 1175296-85-1
• Molecular Formula: C₂₀H₂₀Cl₂FN₃O₂
• Molecular Weight: 424.302
• Mol file: 1175296-85-1.mol

Synonyms:7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine

Chemical Property of 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine

There total 4 articles about 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-(1,2,3,6-tetrahydropyridin-4-yl)-furo[3,2-c]pyridin-6-ylamine (1175296-62-4) → 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine (1175296-85-1)

Guidance literature:

With hydrogen; palladium over charcoal; In ethyl acetate; at 20 ℃; for 1h;

Reference yield:

4-{6-Amino-7-[(R)-1-(2,6-dichloro-3-fluorophenyl)-ethoxy]-furo[3,2-c]pyridin-3-yl}-3,6-dihydro-2H-pyridine-1-carboxylic Acid tert-butyl Ester (1175296-61-3) → 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine (1175296-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; In 1,4-dioxane; ethyl acetate;

DOI:10.1016/j.bmcl.2013.05.074

Reference yield:

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-piperidin-4-yl-furo[3,2-c]pyridin-6-ylamine (1175296-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water / 100 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; potassium carbonate; In 1,4-dioxane; water; ethyl acetate;

DOI:10.1016/j.bmcl.2013.05.074

upstream raw materials:

7-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-(1,2,3,6-tetrahydropyridin-4-yl)-furo[3,2-c]pyridin-6-ylamine

3-bromo-7-[(R)-1-(2,6-dichloro-3-fluorophenyl)-ethoxy]-furo[3,2-c]pyridin-6-ylamine

4-{6-Amino-7-[(R)-1-(2,6-dichloro-3-fluorophenyl)-ethoxy]-furo[3,2-c]pyridin-3-yl}-3,6-dihydro-2H-pyridine-1-carboxylic Acid tert-butyl Ester

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate