3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester

Base Information

• Chemical Name: 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester
• CAS No.: 438547-22-9
• Molecular Formula: C₁₆H₁₂F₃NO₈S
• Molecular Weight: 435.334
• Mol file: 438547-22-9.mol

Synonyms:3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester

Chemical Property of 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester

There total 6 articles about 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester (438547-22-9)

Guidance literature:

Multi-step reaction with 6 steps

1: HNO₃, AcOH

2: aq. LiOH / tetrahydrofuran

3: BBr₃

4: HCl

5: NaH

6: pyridine

With pyridine; hydrogenchloride; lithium hydroxide; nitric acid; boron tribromide; sodium hydride; acetic acid; In tetrahydrofuran;

DOI:10.1021/ja00121a037

Reference yield:

4-hydroxy-3-methoxy-5-nitrobenzoic acid methyl ester (42590-00-1) → 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester (438547-22-9)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. LiOH / tetrahydrofuran

2: BBr₃

3: HCl

4: NaH

5: pyridine

With pyridine; hydrogenchloride; lithium hydroxide; boron tribromide; sodium hydride; In tetrahydrofuran;

DOI:10.1021/ja00121a037

Reference yield:

5-nitrovanillic acid (15785-54-3) → 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester (438547-22-9)

Guidance literature:

Multi-step reaction with 4 steps

1: BBr₃

2: HCl

3: NaH

4: pyridine

With pyridine; hydrogenchloride; boron tribromide; sodium hydride;

DOI:10.1021/ja00121a037

upstream raw materials:

trifluoromethylsulfonic anhydride

3-Benzyloxy-4-hydroxy-5-nitro-benzoic acid methyl ester

4-hydroxy-3-methoxybenzoic acid methyl ester

4-hydroxy-3-methoxy-5-nitrobenzoic acid methyl ester

Downstream raw materials:

3-Benzyloxy-4-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylethynyl]-5-nitro-benzoic acid methyl ester

methyl 3-benzyloxy-4-[(4R,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethynyl-5-nitrobenzoate

3-(6-Acetoxymethyl-6-methoxymethoxy-3,6-dihydro-[1,2]oxazin-2-yl)-5-benzyloxy-4-iodo-benzoic acid methyl ester