(E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

Base Information

Chemical Name:(E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester
CAS No.:250721-82-5
Molecular Formula:C₂₁H₃₄O₆
Molecular Weight:382.497
Hs Code.:

Synonyms:(E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

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Chemical Property of (E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

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Technology Process of (E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

There total 1 articles about (E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 3510-44-9
methyl cis-2-chloroacrylate

: 82012-64-4
diethyl 2-(4-butylcyclohexyl)malonate

: 250721-82-5
(E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

Guidance literature:: diethyl 2-(4-butylcyclohexyl)malonate; With sodium hydride; In tetrahydrofuran; for 0.166667h;

methyl cis-2-chloroacrylate; In tetrahydrofuran; for 14h; Heating;
DOI:10.1021/jm990309x

Reference yield:

: 250721-82-5
(E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

: (E)-4-Carboxy-4-(4-cyclohexyl-butyl)-pent-2-enedioic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 8h; Heating;
DOI:10.1021/jm990309x

Reference yield:

: 250721-82-5
(E)-4-(4-Cyclohexyl-butyl)-4-ethoxycarbonyl-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

: 6-chloro-5-(4-cyclohexyl-butyl)-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / ethanol / 8 h / Heating

2: conc. HCl / 1 h / pH 1 / Heating

3: acetyl chloride / 72 h / Heating

With hydrogenchloride; sodium hydroxide; acetyl chloride; In ethanol; 1: Hydrolysis / 2: Decarboxylation / 3: Cyclization;
DOI:10.1021/jm990309x