(1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:(1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1346004-46-3
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:

Synonyms:(1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of (1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of (1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

There total 13 articles about (1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1346004-58-7
(1S,2S)-ethyl-1-(((S)-1-(4-methoxyphenyl)ethyl)amino)-2,3-dihydro-1H-indene-2-carboxylate hydrochloride

: 1346004-46-3
(1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With sodium methylate; In ethanol; for 48h; Reflux; Inert atmosphere;
DOI:10.1021/ol202750u

Reference yield: 18.0%

: 1346004-12-3
(S,E)-ethyl 3-(2-((1-(4-methoxyphenyl)ethylimino)methyl)phenyl)propanoate

: 1346004-46-3
(1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 8h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ol202750u

Reference yield:

: 1346004-27-0
(E)-ethyl 3-(2-(1,3-dioxan-2-yl)phenyl)acrylate

: 1346004-46-3
(1S,2R)-ethyl 1-((S)-1-(4-ethoxyphenyl)ethylamino)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: cobalt(II) chloride hexahydrate / ethanol / 0.5 h / 0 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: acetic acid / water / 12 h / 20 °C / Inert atmosphere

3.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

3.2: 5 h / 20 °C / Inert atmosphere

4.1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

5.1: hydrogenchloride / diethyl ether / 5 h / Reflux; Inert atmosphere

6.1: sodium methylate / ethanol / 48 h / Reflux; Inert atmosphere

With hydrogenchloride; 15-crown-5; cobalt(II) chloride hexahydrate; sodium methylate; sodium hexamethyldisilazane; magnesium sulfate; acetic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/ol202750u