5-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethoxy}-2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenol

Base Information

Chemical Name:5-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethoxy}-2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenol
CAS No.:1010867-37-4
Molecular Formula:C₂₈H₂₉FN₄O₃
Molecular Weight:488.562
Hs Code.:
Mol file:1010867-37-4.mol

Synonyms:2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethoxy}phenol

Suppliers and Price of 5-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethoxy}-2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethoxy}-2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenol

Chemical Property:

Boiling Point:694.6±55.0 °C(Predicted)
PKA:8.38±0.35(Predicted)
Density:1.260±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 5-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethoxy}-2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenol

There total 3 articles about 5-{2-[4-(4-fluorophenyl)-1-piperazinyl]ethoxy}-2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 903189-77-5
3-(4-methoxyphenyl)-7-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethoxy}-4H-chromen-4-one

: 1010867-37-4
2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethoxy}phenol

Guidance literature:: With hydrazine hydrate; In ethanol; Reflux;
DOI:10.1007/s10600-013-0500-9

Reference yield:

: 485-72-3
7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on

: 1010867-37-4
2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethoxy}phenol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 75 - 80 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / Reflux

3: hydrazine hydrate / ethanol / Reflux

With potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s10600-013-0500-9

Reference yield:

: 6716-74-1
7-(2-bromoethoxy)-3-(4-methoxyphenyl)-4H-chromen-4-one

: 1010867-37-4
2-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-{2-[4-(4-fluorophenyl)piperazin-1-yl]ethoxy}phenol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / Reflux

2: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol;
DOI:10.1007/s10600-013-0500-9