N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide

Base Information

• Chemical Name: N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide
• CAS No.: 1381763-08-1
• Molecular Formula: C₃₁H₄₄N₈O₅
• Molecular Weight: 608.741

Synonyms:N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide

Chemical Property of N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide

There total 4 articles about N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)-5-oxopentanoic acid (1381763-07-0) + 4-(tert-butyl)-1,2-diaminobenzene (68176-57-8) → N1-(2-amino-4-(tert-butyl)phenyl)-N5-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N5-isopropylglutaramide (1381763-08-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

Pentanedioic acid, monomethyl ester (1501-27-5) → N1-(2-amino-4-(tert-butyl)phenyl)-N5-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N5-isopropylglutaramide (1381763-08-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

2.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / 20 °C

2.2: pH 5 - 6

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

9-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-[[(propan-2-yl)amino]methyl]tetrahydro-2H-furano[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-amine → N1-(2-amino-4-(tert-butyl)phenyl)-N5-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N5-isopropylglutaramide (1381763-08-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

2.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / 20 °C

2.2: pH 5 - 6

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

Pentanedioic acid, monomethyl ester

5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)-5-oxopentanoic acid

4-(tert-butyl)-1,2-diaminobenzene

methyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)-5-oxopentanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1381763-08-1 N₁-(2-amino-4-(tert-butyl)phenyl)-N₅-(((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)-N₅-isopropylglutaramide

Send

Send

Metric Ton KG G Pound L ML

Send

Send