2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

Base Information

Chemical Name:2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose
CAS No.:1415238-59-3
Molecular Formula:C₃₃H₃₉F₂NO₂₀
Molecular Weight:807.664
Hs Code.:

Synonyms:2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

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Chemical Property of 2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

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Technology Process of 2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

There total 2 articles about 2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1415238-58-2
2-formyl-4-nitro 2,3,4,6,2′ ,3′,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

: 1415238-59-3
2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja309790w

Reference yield:

: 97-51-8
5-Nitrosalicylaldehyde

: 1415238-59-3
2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 0 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water;
DOI:10.1021/ja309790w

Reference yield:

: 1415238-59-3
2-difluromethyl-4-nitro 2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

: 1415238-68-4
4-(hex-5-yneamide)-2-difluromethyl-1-phenoxyl-2,3,4,6,2′ ,3′ ,4′ ,6′-hepta-O-acetyl-1-phenoxyl-α-D-lactopyranose

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja309790w