cis-(1S)-N-methyl-7-(4-(N⁽¹⁾-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Base Information

• Chemical Name: cis-(1S)-N-methyl-7-(4-(N⁽¹⁾-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
• CAS No.: 291306-30-4
• Molecular Formula: C₂₃H₂₅Cl₂N₃O
• Molecular Weight: 430.377

Synonyms:cis-(1S)-N-methyl-7-(4-(N⁽¹⁾-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Chemical Property of cis-(1S)-N-methyl-7-(4-(N⁽¹⁾-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

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Technology Process of cis-(1S)-N-methyl-7-(4-(N⁽¹⁾-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

There total 1 articles about cis-(1S)-N-methyl-7-(4-(N⁽¹⁾-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (291306-20-2) + N-1-ethoxymethyl-4-iodo-pyrazole (291306-29-1) → cis-(1S)-N-methyl-7-(4-(N(1)-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-30-4)

Guidance literature:

N-1-ethoxymethyl-4-iodo-pyrazole; With n-butyllithium; In diethyl ether; hexane; at -95 ℃; for 0.166667h;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; for 0.666667h;

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; for 16h; Heating / reflux;

Reference yield: 46.0%

cis-(1S)-N-methyl-7-(4-(N(1)-ethoxymethyl)pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-30-4) → Cis-(1S)-N-methyl-7-(4-pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291305-51-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 16h; Heating / reflux;

upstream raw materials:

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

N-1-ethoxymethyl-4-iodo-pyrazole

Downstream raw materials:

Cis-(1S)-N-methyl-7-(4-pyrazolyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

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