C₂₁H₂₇N₅O₄

Base Information

• Chemical Name: C₂₁H₂₇N₅O₄
• CAS No.: 1438021-35-2
• Molecular Formula: C₂₁H₂₇N₅O₄
• Molecular Weight: 413.476
• Mol file: 1438021-35-2.mol

Synonyms:C₂₁H₂₇N₅O₄

Chemical Property of C₂₁H₂₇N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₇N₅O₄

There total 8 articles about C₂₁H₂₇N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

C22H29N5O4*ClH (1438021-20-5) → C21H27N5O4 (1438021-35-2)

Guidance literature:

With lithium hydroxide monohydrate; water; In methanol; at 20 ℃; for 12h;

DOI:10.1021/ja4025148

Reference yield:

C20H23NO6 (1438020-58-6) → C21H27N5O4 (1438021-35-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; formic acid; hydrogen / methanol / 2 h

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 70 °C

2.2: 12 h / 20 °C

3.1: trifluoroacetic acid; hydrogenchloride / dichloromethane; water / 12 h / 20 °C

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h / 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran / 12 h / 20 °C

6.1: water; lithium hydroxide monohydrate / methanol / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; formic acid; lithium hydroxide monohydrate; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja4025148

Reference yield:

C25H34N2O5 (1438020-76-8) → C21H27N5O4 (1438021-35-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid; hydrogenchloride / dichloromethane; water / 12 h / 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 12 h / 20 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 12 h / 20 °C

4.1: water; lithium hydroxide monohydrate / methanol / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja4025148

upstream raw materials:

C₂₀H₂₃NO₆

C₁₃H₁₇NO₆

C₁₆H₁₇NO₄

C₂₅H₃₄N₂O₅