7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline

Base Information

• Chemical Name: 7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline
• CAS No.: 320366-84-5
• Molecular Formula: C₂₂H₁₆BrFN₂O₃
• Molecular Weight: 455.283
• Mol file: 320366-84-5.mol

Synonyms:7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline

Chemical Property of 7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline

There total 1 articles about 7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-fluorophenol (2105-94-4) + 7-benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) → 7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline (320366-84-5)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 5h;

Reference yield:

7-benzyloxy-4-(4-bromo-2-fluorophenoxy)-6-methoxyquinazoline (320366-84-5) → 4-(4-Bromo-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline (288384-43-0)

Guidance literature:

With trifluoroacetic acid; for 3h; Heating / reflux;

upstream raw materials:

4-bromo-2-fluorophenol

7-benzyloxy-4-chloro-6-methoxyquinazoline

Downstream raw materials:

4-(4-Bromo-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline