N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

Base Information

• Chemical Name: N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide
• CAS No.: 1133853-57-2
• Molecular Formula: C₂₂H₁₇F₄N₃O
• Molecular Weight: 415.39

Synonyms:N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

Chemical Property of N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

Chemical Property:

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Technology Process of N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

There total 1 articles about N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-1,7-naphthyridine (1133853-58-3) + para-fluorophenyl isocyanate (1195-45-5) → N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide (1133853-57-2)

Guidance literature:

In 1,2-dichloro-ethane; at 20 ℃; for 1h;

Reference yield:

N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide (1133853-57-2) → N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide N-oxide (1133854-67-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide (1133853-57-2) → (S)-N-(4-Fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide (1133853-60-7) + (R)-N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide (1133853-59-4)

Guidance literature:

Purification / work up; Resolution of racemate;

upstream raw materials:

8-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-1,7-naphthyridine

para-fluorophenyl isocyanate

Downstream raw materials:

(S)-N-(4-Fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

(R)-N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide

N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide N-oxide

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