3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride

Base Information

• Chemical Name: 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride
• CAS No.: 1258979-12-2
• Molecular Formula: C₁₆H₁₉N₇O₂*ClH
• Molecular Weight: 377.834
• Mol file: 1258979-12-2.mol

Synonyms:3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride

Chemical Property of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride

There total 3 articles about 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carbonyl chloride (113942-58-8) + N,N-diethylaniline (93-05-0) → 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride (1258979-12-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.3390/molecules15129427

Reference yield:

temozolomide (85622-93-1) → 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride (1258979-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; sodium nitrite / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / 2.5 h / Reflux

3: tetrahydrofuran / 3 h / 20 °C

With thionyl chloride; sulfuric acid; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran;

DOI:10.3390/molecules15129427

Reference yield:

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrahydro-8-carboxylic acid (113942-30-6) → 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-[N-(p-diethylamino)phenyl]carboxamide hydrochloride (1258979-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 2.5 h / Reflux

2: tetrahydrofuran / 3 h / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.3390/molecules15129427

upstream raw materials:

temozolomide

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrahydro-8-carboxylic acid

3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carbonyl chloride

N,N-diethylaniline

Refernces