(3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

Base Information

Chemical Name:(3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol
CAS No.:96685-47-1
Molecular Formula:C₂₄H₃₈O₃S
Molecular Weight:406.63
Hs Code.:

Synonyms:(3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

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Chemical Property of (3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

Chemical Property:

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Technology Process of (3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

There total 12 articles about (3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 96700-56-0
2(S)-methyl-3(R)-(1(R),-dimethylhexyl)-1(S)-<(phenylsulfonyl)methyl>-2-(2,3-epoxypropyl)cyclopentane

: (R)-6-((1R,3aR,6aR)-4-Benzenesulfonyl-5-hydroxymethyl-6a-methyl-octahydro-pentalen-1-yl)-heptan-2-ol

: 96685-47-1
(3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1021/jo00376a049

Reference yield: 50.0%

: 96700-56-0
2-[(1R,2R,5R)-2-Benzenesulfonylmethyl-5-(1,5-dimethyl-hexyl)-1-methyl-cyclopentylmethyl]-oxirane

: 96685-48-2
[(3aR,4R,6aR)-1-Benzenesulfonyl-4-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-pentalen-2-yl]-methanol

: 96685-47-1
(3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-(1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

: 96843-37-7,96894-96-1
C₂₅H₃₆O₄S

: 96685-47-1
(3R,3aR,7R,7aR)-7-Benzenesulfonyl-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-5-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / HCl, H₂ / 5percent Pd/C / methanol / 5 h / Ambient temperature

2: 98 percent / p-toluenesulfonic acid / 10 h / Heating

3: 1.) O₃, 2.) LiOH / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) THF, RT, 2 h

4: 73 percent / camphorsulfonic acid / benzene / 2 h / Heating

5: 72 percent / LiAlH₄ / tetrahydrofuran / 9 h / Ambient temperature

6: 93 percent / 4-(dimethylamino)pyridine, pyridine / 5 h / Ambient temperature

7: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

8: 95 percent / HCl / acetone / 6 h / Ambient temperature

9: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, 0 deg C, 30 min

10: 50 percent / LDA / tetrahydrofuran / 0.17 h / -78 °C

With pyridine; hydrogenchloride; dmap; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; camphor-10-sulfonic acid; hydrogen; toluene-4-sulfonic acid; ozone; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1021/jo00376a049