1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate

Base Information

• Chemical Name: 1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate
• CAS No.: 1174651-90-1
• Molecular Formula: C₃₅H₄₁NO₁₀S
• Molecular Weight: 667.777
• Mol file: 1174651-90-1.mol

Synonyms:1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate

Chemical Property of 1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate

There total 1 articles about 1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl (p-tolyl(tosyl)methyl)carbamate + Phenyl-methanesulfonic acid (3aR,5R,6R,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester (412021-12-6) → 1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate (1174651-90-1)

Guidance literature:

Phenyl-methanesulfonic acid (3aR,5R,6R,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃;

benzyl (p-tolyl(tosyl)methyl)carbamate; In tetrahydrofuran; hexane; at -100 - 20 ℃;

DOI:10.1055/s-0029-1216643

Reference yield:

1,2:5,6-di-O-isopropylidene-α-d-allofuranos-3-yl (1S,2R)-2-[(benzyloxycarbonyl)amino]-1-phenyl-2-(4-tolyl)ethanesulfonate (1174651-90-1) → C23H23NO5S

Guidance literature:

With trifluoroacetic acid; In ethanol; for 15h; Reflux;

DOI:10.1055/s-0029-1216643

upstream raw materials:

Phenyl-methanesulfonic acid (3aR,5R,6R,6aR)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester