2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

Base Information

Chemical Name:2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile
CAS No.:1428477-38-6
Molecular Formula:C₂₃H₂₁FN₆O
Molecular Weight:416.458
Hs Code.:

Synonyms:2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

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Chemical Property of 2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

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Technology Process of 2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

There total 8 articles about 2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428477-34-2
2-fluoro-5-[2-(4-hydroxy-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]benzonitrile

: 1428477-38-6
2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 12h; Reflux;

Reference yield:

: 1428478-50-5
1-(4-ethynyl-4-hydroxypiperidin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone

: 1428477-38-6
2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; triphenylphosphine / tetrahydrofuran / 3 h / 60 °C / Sealed tube; Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 12 h / 760.05 Torr

3: toluene-4-sulfonic acid / benzene / 12 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol; benzene;

Reference yield:

: 185132-51-8
4-hydroxy-4-trimethylsilanylethynylpiperidine-1-carboxylic acid tert-butyl ester

: 1428477-38-6
2-fluoro-5-[2-(1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}-1,2,3,6-tetrahydropyridin-4-yl)ethyl]benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 5 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 5 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; triphenylphosphine / tetrahydrofuran / 3 h / 60 °C / Sealed tube; Inert atmosphere

5: palladium on activated charcoal; hydrogen / methanol / 12 h / 760.05 Torr

6: toluene-4-sulfonic acid / benzene / 12 h / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; benzene;