Technology Process of 4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
There total 9 articles about 4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
toluene;
at 80 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: morpholine; sulfur / ethanol / 12 h / 70 °C / Inert atmosphere
2: chloroform / 1 h / 70 °C
3: sodium iodide / tetrahydrofuran / 2 h / 60 °C
4: ammonia / tetrahydrofuran / 3.5 h / -60 - 20 °C
5: acetic acid / isopropyl alcohol / 3 h / 90 °C
6: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C
7: hydrazine hydrate / methanol / 1 h / 0 °C
8: toluene / 1 h / 80 °C
With
morpholine; tetraphosphorus decasulfide; hydrazine hydrate; ammonia; sodium carbonate; sulfur; acetic acid; sodium iodide;
In
tetrahydrofuran; methanol; ethanol; chloroform; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: chloroform / 1 h / 70 °C
2: sodium iodide / tetrahydrofuran / 2 h / 60 °C
3: ammonia / tetrahydrofuran / 3.5 h / -60 - 20 °C
4: acetic acid / isopropyl alcohol / 3 h / 90 °C
5: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C
6: hydrazine hydrate / methanol / 1 h / 0 °C
7: toluene / 1 h / 80 °C
With
tetraphosphorus decasulfide; hydrazine hydrate; ammonia; sodium carbonate; acetic acid; sodium iodide;
In
tetrahydrofuran; methanol; chloroform; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
