1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione
CAS No.:1021461-53-9
Molecular Formula:C₄₅H₅₁N₃O₈Si
Molecular Weight:790.001
Hs Code.:

1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Synonyms:1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

There total 2 articles about 1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 488114-56-3
C₄₂H₄₉NO₈Si

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1021461-60-8
(3S)-3-(3-O-benzoyl-4-O-tert-butyldiphenylsilyl-1,2-O-isopropylidene-D-xylotetritol-1-yl)-2-benzyl-2,3-dihydroisoxazole

: 1021461-53-9
1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: thymin; With bis-(trimethylsilyl)acetamide; In acetonitrile; at 70 ℃; for 0.25h;

C₄₂H₄₉NO₈Si; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 70 ℃; for 2h; Further stages.;
DOI:10.1016/j.tet.2008.01.133

Reference yield:

: 488114-56-3
C₄₂H₄₉NO₈Si

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1021461-53-9
1-[(3S,5R)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4(1H,3H)-dione

: 1021461-84-6
1-[(3S,5S)-2-benzyl-3-(1,2-O-isopropylidene-3-O-benzoyl-4-O-tert-butyldiphenylsilyl-D-xylos-1-yl)isoxazolidin-5-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: thymin; With bis-(trimethylsilyl)acetamide; In dichloromethane; at 20 ℃;

C₄₂H₄₉NO₈Si; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2008.01.133