(2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

Base Information

Chemical Name:(2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)
CAS No.:1266348-26-8
Molecular Formula:C₃₄H₃₀O₈
Molecular Weight:566.607
Hs Code.:

Synonyms:(2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

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Technology Process of (2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

There total 6 articles about (2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 20628-06-2
2-hydroxy-4,5-dimethoxyacetophenone

: 66-98-8
4,4'-diformylbiphenyl

: 1266348-26-8
(2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

Guidance literature:: With potassium hydroxide; In ethanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c7ob00804j

Reference yield: 57.0%

: 90-24-4
2-hydroxy-4,6-dimethoxyacetophenone

: 66-98-8
4,4'-diformylbiphenyl

: 1266348-26-8
(2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

Guidance literature:: With potassium hydroxide; In methanol; at 20 ℃; for 48h;
DOI:10.1007/s12272-010-1205-2

Reference yield:

: 5798-75-4
Ethyl 4-bromobenzoate

: 1266348-26-8
(2E,2′E)-3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one)

Guidance literature:: Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 20 - 100 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux; Cooling with ice

4: pyridinium chlorochromate / dichloromethane / 2 h / Molecular sieve; Inert atmosphere; Reflux

5: potassium hydroxide / methanol / 48 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; lithium aluminium tetrahydride; potassium acetate; pyridinium chlorochromate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Suzuki-Miyaura reaction / 5: Claisen-Schmidt condensation;
DOI:10.1007/s12272-010-1205-2