5-Chlorobenzo[d][1,3]dioxol-4-amine

Base Information

Chemical Name:5-Chlorobenzo[d][1,3]dioxol-4-amine
CAS No.:379228-45-2
Molecular Formula:C7H6 Cl N O2
Molecular Weight:171.583
Hs Code.:2932999099
DSSTox Substance ID:DTXSID80463654
Wikidata:Q72517218
Mol file:379228-45-2.mol

Synonyms:(14C)-5-chloro-1,3-benzodioxol-4-amine;5-chloro-1,3-benzodioxol-4-amine

Suppliers and Price of 5-Chlorobenzo[d][1,3]dioxol-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Chloro-1,3-benzodioxol-4-amine
100mg
$ 140.00

Crysdot
5-Chlorobenzo[d][1,3]dioxol-4-amine 95+%
1g
$ 474.00

Chemenu
5-Chlorobenzo[d][1,3]dioxol-4-amine 95%
1g
$ 443.00

Biosynth Carbosynth
5-Chlorobenzo[1,3]dioxol-4-ylamine
500 mg
$ 325.00

Biosynth Carbosynth
5-Chlorobenzo[1,3]dioxol-4-ylamine
250 mg
$ 212.50

Biosynth Carbosynth
5-Chlorobenzo[1,3]dioxol-4-ylamine
50 mg
$ 72.00

Biosynth Carbosynth
5-Chlorobenzo[1,3]dioxol-4-ylamine
1 g
$ 500.00

American Custom Chemicals Corporation
5-CHLORO-1,3-BENZODIOXOL-4-AMINE 95.00%
5G
$ 2136.75

American Custom Chemicals Corporation
5-CHLORO-1,3-BENZODIOXOL-4-AMINE 95.00%
1G
$ 1016.40

Alichem
5-Chlorobenzo[d][1,3]dioxol-4-amine
1g
$ 942.85

Total 34 raw suppliers

Chemical Property of 5-Chlorobenzo[d][1,3]dioxol-4-amine

Chemical Property:

Vapor Pressure:0.00519mmHg at 25°C
Boiling Point:275.1ºC at 760 mmHg
PKA:2.17±0.20(Predicted)
Flash Point:120.2ºC
PSA：44.48000
Density:1.494g/cm3
LogP:2.23210
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:171.0087061
Heavy Atom Count:11
Complexity:155

Purity/Quality:

99%, ^*data from raw suppliers

5-Chloro-1,3-benzodioxol-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1OC2=C(O1)C(=C(C=C2)Cl)N
Uses 5-Chloro-1,3-benzodioxol-4-amine was used to prepare chloro(methylthio)thiazolopyridine via substitution reaction.

Technology Process of 5-Chlorobenzo[d][1,3]dioxol-4-amine

There total 3 articles about 5-Chlorobenzo[d][1,3]dioxol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 379229-84-2
tert-butyl (5-chloro-1,3-benzodioxol-4-yl)carbamate

: 379228-45-2
5-chlorobenzo[d][1,3]dioxolcyclopenten-4-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm030317k

Reference yield:

: 7228-38-8
5-chloro-1,3-benzodioxole

: 379228-45-2
5-chlorobenzo[d][1,3]dioxolcyclopenten-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 84 percent / tetrahydrofuran / -78 - 20 °C

2.1: 81 percent / diphenoxyphosphoryl azide; Et₃N / dioxane / 4 h / 100 °C

3.1: 93 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 2.1: Curtius rearrangement;
DOI:10.1021/jm030317k

Reference yield:

: 379229-83-1
5-chloro-1,3-benzodioxole-4-carboxylic acid

: 379228-45-2
5-chlorobenzo[d][1,3]dioxolcyclopenten-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / diphenoxyphosphoryl azide; Et₃N / dioxane / 4 h / 100 °C

2: 93 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; 1: Curtius rearrangement;
DOI:10.1021/jm030317k