diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

Base Information

Chemical Name:diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate
CAS No.:1627153-02-9
Molecular Formula:C₂₉H₃₃NO₅
Molecular Weight:475.585
Hs Code.:

Synonyms:diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

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Chemical Property of diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

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Technology Process of diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

There total 5 articles about diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1627153-26-7
1-[(1-methyl-1H-indol-3-yl)(phenyl)methyl]cyclopent-3-enol

: 140-88-5,9003-32-1
ethyl acrylate

: 1627153-02-9
diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 0 - 20 ℃; for 36h; Schlenk technique; Inert atmosphere;
DOI:10.1002/adsc.201301108

Reference yield:

: 1627153-22-3
4-[(1-methyl-1H-indol-3-yl)(phenyl)methyl]hepta-1,6-dien-4-ol

: 1627153-02-9
diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

1.2: Schlenk technique; Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 36 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1002/adsc.201301108

Reference yield:

: 1062136-70-2
methyl 2-(1-methyl-1H-indol-3-yl)-2-phenylacetate

: 1627153-02-9
diethyl (2E,7E)-5-hydroxy-5-[(1-methyl-1H-indol-3-yl)-(phenyl)methyl]nona-2,7-dienedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

1.2: Schlenk technique; Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

2.2: Schlenk technique; Inert atmosphere

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 36 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/adsc.201301108