C₂₃H₂₂FNO₅S

Base Information

• Chemical Name: C₂₃H₂₂FNO₅S
• CAS No.: 1374233-31-4
• Molecular Formula: C₂₃H₂₂FNO₅S
• Molecular Weight: 443.496
• Mol file: 1374233-31-4.mol

Synonyms:C₂₃H₂₂FNO₅S

Chemical Property of C₂₃H₂₂FNO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₂FNO₅S

There total 11 articles about C₂₃H₂₂FNO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-5-methoxyaniline (59557-92-5) → C23H22FNO5S (1374233-31-4)

Guidance literature:

Multi-step reaction with 11 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: triethylamine; lithium chloride / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere

4.1: diethylzinc / hexane; toluene / 0 - 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 24 h / 0 - 20 °C

6.1: boron tribromide / dichloromethane / 0.33 h / 0 °C

6.2: Cooling with ice

7.1: triethylamine / dmap / tetrahydrofuran / 1.5 h / 0 - 20 °C

8.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Reflux

10.1: N-iodo-succinimide / chloroform; trifluoroacetic acid / 3 h / 20 °C

11.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 60 °C

With piperidine; pyridine; N-Bromosuccinimide; N-iodo-succinimide; tetrabutyl ammonium fluoride; diethylzinc; boron tribromide; potassium carbonate; triethylamine; lithium chloride; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;

Reference yield:

4-bromo-3-nitroanizole (5344-78-5) → C23H22FNO5S (1374233-31-4)

Guidance literature:

Multi-step reaction with 12 steps

1.1: acetic acid; zinc / ethanol / 20 °C

2.1: pyridine / dichloromethane / 0.5 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

4.1: triethylamine; lithium chloride / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere

5.1: diethylzinc / hexane; toluene / 0 - 20 °C

6.1: N-Bromosuccinimide / dichloromethane / 24 h / 0 - 20 °C

7.1: boron tribromide / dichloromethane / 0.33 h / 0 °C

7.2: Cooling with ice

8.1: triethylamine / dmap / tetrahydrofuran / 1.5 h / 0 - 20 °C

9.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Reflux

11.1: N-iodo-succinimide / chloroform; trifluoroacetic acid / 3 h / 20 °C

12.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 60 °C

With piperidine; pyridine; N-Bromosuccinimide; N-iodo-succinimide; tetrabutyl ammonium fluoride; diethylzinc; boron tribromide; potassium carbonate; acetic acid; triethylamine; lithium chloride; zinc; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;

Reference yield:

C14H19NO3S (1374233-24-5) → C23H22FNO5S (1374233-31-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dichloromethane / 24 h / 0 - 20 °C

2.1: boron tribromide / dichloromethane / 0.33 h / 0 °C

2.2: Cooling with ice

3.1: triethylamine / dmap / tetrahydrofuran / 1.5 h / 0 - 20 °C

4.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Reflux

6.1: N-iodo-succinimide / chloroform; trifluoroacetic acid / 3 h / 20 °C

7.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 60 °C

With piperidine; N-Bromosuccinimide; N-iodo-succinimide; tetrabutyl ammonium fluoride; boron tribromide; triethylamine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; trifluoroacetic acid;

upstream raw materials:

2-bromo-5-methoxyaniline

4-bromo-3-nitroanizole

C₁₃H₁₇NO₃S

C₁₄H₁₉NO₃S

Downstream raw materials:

C₂₂H₂₀FNO₅S

C₂₃H₂₃FN₂O₄S