(1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

Base Information

Chemical Name:(1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate
CAS No.:1403953-59-2
Molecular Formula:C₂₀H₂₀N₂O₃
Molecular Weight:336.39
Hs Code.:

Synonyms:(1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

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Chemical Property of (1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

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Technology Process of (1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

There total 3 articles about (1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1403953-57-0
(1S,2S)-2-(diphenylmethylideneamino)cyclopropanecarboxylic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1403953-59-2
(1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2012.09.078

Reference yield:

: 1403953-52-5
(3R)-benzyl 3-(diphenylmethylideneamino)-4-iodobutanoate

: 1403953-59-2
(1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2: sodium hydroxide / methanol; water / 20 h / 20 °C / Cooling with ice

3: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With 4-methyl-morpholine; potassium hexamethylsilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.tet.2012.09.078

Reference yield:

: 1403953-55-8
(1S,2S)-benzyl 2-(diphenylmethylideneamino)cyclopropanecarboxylate

: 1403953-59-2
(1'S,2'S)-methyl [(2'-diphenylmethylideneaminocyclopropane)carbonyl]aminoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 20 h / 20 °C / Cooling with ice

2: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1016/j.tet.2012.09.078