2-bromo-3,5-dimethoxybibenzyl

Base Information

• Chemical Name: 2-bromo-3,5-dimethoxybibenzyl
• CAS No.: 133462-93-8
• Molecular Formula: C₁₆H₁₇BrO₂
• Molecular Weight: 321.214
• Mol file: 133462-93-8.mol

Synonyms:2-bromo-3,5-dimethoxybibenzyl

Chemical Property of 2-bromo-3,5-dimethoxybibenzyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-3,5-dimethoxybibenzyl

There total 2 articles about 2-bromo-3,5-dimethoxybibenzyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

1,3-dimethoxy-5-(2-phenylethyl)benzene (78916-50-4) → 2,6-dibromo-3,5-dimethoxy-bibenzyl (133462-94-9) + 2-bromo-3,5-dimethoxybibenzyl (133462-93-8)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; for 12h;

DOI:10.1016/0031-9422(91)84129-G

Reference yield:

dihydropinosylvin monomethyl ether (17635-59-5) → 2-bromo-3,5-dimethoxybibenzyl (133462-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.90 g / K₂CO₃ / acetone

2: 79.5 percent / NBS / dimethylformamide / 12 h

With N-Bromosuccinimide; potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/0031-9422(91)84129-G

Reference yield:

2-bromo-3,5-dimethoxybibenzyl (133462-93-8) → 3,5-dihydroxy-2-(2,3-epoxy-3-methylbutyl)bibenzyl (133462-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) n-BuLi / 1) diethyl ether, 1 h, reflux, 2) 1 h, 40 deg C

2: 19.8 percent / BBr₃ / CH₂Cl₂ / 2 h / -10 - 0 °C

3: 5 mg / m-CPBA / CHCl₃ / 2 h / Ambient temperature

With n-butyllithium; boron tribromide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform;

DOI:10.1016/0031-9422(91)84129-G

upstream raw materials:

1,3-dimethoxy-5-(2-phenylethyl)benzene

dihydropinosylvin monomethyl ether

Downstream raw materials:

1,3-dimethoxy-5-(2-phenylethyl)benzene

2-((E)-3,7-Dimethyl-octa-2,6-dienyl)-1,5-dimethoxy-3-phenethyl-benzene

dihydropinosylvin

2,6-dibromo-3,5-dimethoxy-bibenzyl