methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate

Base Information

• Chemical Name: methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate
• CAS No.: 942998-95-0
• Molecular Formula: C₁₇H₂₅NO₅
• Molecular Weight: 323.389
• Mol file: 942998-95-0.mol

Synonyms:methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate

Chemical Property of methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate

There total 2 articles about methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 4-hydroxy-3,5-dimethylbenzoate (34137-14-9) + 2-(tert-butoxycarbonylamino)ethyl-4-methylbenzenesulfonate (158690-56-3) → methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate (942998-95-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

3,5-dimethyl-4-hydroxybenzoic acid (4919-37-3) → methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate (942998-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 3 h / Heating

2: CsCO₃ / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm701359z

Reference yield: 97.0%

methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate (942998-95-0) → 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoic acid (942998-96-1)

Guidance literature:

methyl 4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoate; With potassium hydroxide; In methanol; water; at 50 ℃; for 3h;

With hydrogenchloride; In water;

upstream raw materials:

methyl 4-hydroxy-3,5-dimethylbenzoate

2-(tert-butoxycarbonylamino)ethyl-4-methylbenzenesulfonate

3,5-dimethyl-4-hydroxybenzoic acid

Downstream raw materials:

4-[2-(tert-butyloxycarbonylamino)ethoxy]-3,5-dimethylbenzoic acid

C₂₅H₃₄N₂O₅

C₂₆H₃₆N₂O₆

C₂₈H₄₀N₂O₆