N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Base Information

Chemical Name:N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline
CAS No.:744253-79-0
Molecular Formula:C₂₃H₂₆N₂O₅
Molecular Weight:410.47
Hs Code.:

Synonyms:N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

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Chemical Property of N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

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Technology Process of N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

There total 7 articles about N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 54132-75-1
3,5-dimethylphenyl isocyanate

: 744253-63-2
N-(3,5-dimethylbenzoyl)-(4R)-hydroxy-L-proline

: 744253-79-0
N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Guidance literature:: With pyridine; In dichloromethane; at 115 ℃; for 22h;
DOI:10.1055/s-2004-822384

Reference yield: 30.0%

: 6613-44-1
3,5-dimethylbenzoyl chloride

: 744253-84-7
(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

: 744253-79-0
N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Guidance literature:: With sodium hydroxide; at 20 ℃; for 1.5h;
DOI:10.1055/s-2004-822384

Reference yield:

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 744253-79-0
N-(3,5-dimethylbenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / pyridine / 22 h / 115 °C

2: 73 percent / TFA / CH₂Cl₂ / 0.5 h / 20 °C

3: 30 percent / aq. NaOH / 1.5 h / 20 °C

With pyridine; sodium hydroxide; trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-2004-822384