Technology Process of ethyl 4,4-difluoro-1-(methoxymethyl)cyclohexane carboxylate
There total 3 articles about ethyl 4,4-difluoro-1-(methoxymethyl)cyclohexane carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 4,4-difluoro-1-(hydroxymethyl)cyclohexanecarboxylate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.5h;
dimethyl sulfate;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 3 h / -78 - -20 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: methanesulfonic acid / dichloromethane / 2 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
3.2: 20 °C
With
n-butyllithium; methanesulfonic acid; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: methanesulfonic acid / dichloromethane / 2 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
2.2: 20 °C
With
methanesulfonic acid; sodium hydride;
In
tetrahydrofuran; dichloromethane; mineral oil;