4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

Base Information

Chemical Name:4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl
CAS No.:912818-52-1
Molecular Formula:C₄₀H₄₀O₇
Molecular Weight:632.753
Hs Code.:

Synonyms:4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

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Chemical Property of 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

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Technology Process of 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

There total 9 articles about 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 912818-46-3
1,2-dideoxy-1β-[4-(3,4-dimethoxyphenyl)phenyl]-D-ribofuranose

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 912818-52-1
4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2006.05.072

Reference yield:

: 898828-50-7
4-(2'-deoxy-β-D-ribofuranosyl)-1-bromobenzene

: 912818-52-1
4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 4-(dimethylamino)pyridine; pyridine / 16 h / 20 °C

2: 93 percent / KF; 2-(di-tert-butylphosphino)biphenyl / Pd(OAc)2 / tetrahydrofuran / 16 h / 20 °C

3: 92 percent / K₂CO₃ / methanol / 20 °C

4: 90 percent / pyridine / 4 h / 20 °C

With pyridine; dmap; potassium fluoride; potassium carbonate; johnphos; palladium diacetate; In tetrahydrofuran; methanol; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.05.072

Reference yield:

: 912818-31-6
4-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)-1-bromobenzene

: 912818-52-1
4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-3,4-dimethoxybiphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / KF; 2-(di-tert-butylphosphino)biphenyl / Pd(OAc)2 / tetrahydrofuran / 16 h / 20 °C

2: 92 percent / K₂CO₃ / methanol / 20 °C

3: 90 percent / pyridine / 4 h / 20 °C

With pyridine; potassium fluoride; potassium carbonate; johnphos; palladium diacetate; In tetrahydrofuran; methanol; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.05.072