(R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Base Information

Chemical Name:(R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol
CAS No.:343775-78-0
Molecular Formula:C₂₂H₂₉NO₂
Molecular Weight:339.478
Hs Code.:

Synonyms:(R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Suppliers and Price of (R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

There total 11 articles about (R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 343775-84-8
[(5R,8R)-4-Benzyloxy-8-((R)-2-hydroxy-1-methyl-ethyl)-2,5-dimethyl-5,6,7,8-tetrahydro-naphthalen-1-yl]-carbamic acid tert-butyl ester

: 343775-78-0
(R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1021/ja010221k

Reference yield:

: 343775-72-4
(3E,5E)-(R)-2-methyl-hepta-3,5-dienoic acid

: 343775-78-0
(R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / DCC; HOBt / tetrahydrofuran / 20 °C

2: Pb(OAc)4 / ethyl acetate / 20 °C

3: 100 percent / H₂ / Pd/C / methanol / 6 h / 20 °C / 760.05 Torr

4: 63 percent / K₂CO₃ / acetone / 24 h / Heating

5: 99 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / Heating

6: 96 percent / potassium carbonate / 1 h / 20 °C

7: 73 percent / diisobutylaluminium hydride / CH₂Cl₂; heptane / 1 h / 0 °C

8: 91 percent / aq. HCl / tetrahydrofuran / 48 h / 20 °C

With lead(IV) acetate; hydrogenchloride; dmap; hydrogen; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ethyl acetate; acetone; 2: Diels-Alder reaction;
DOI:10.1021/ja010221k

Reference yield:

: (R)-tert-butyl-dimethyl-(2-methyl-hepta-3,5-dienyloxy)-silane

: 343775-78-0
(R)-2-((1R,4R)-8-Amino-5-benzyloxy-4,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: 50 percent / chromium trioxide; conc. sulfuric acid / acetone; H₂O / 2 h / -10 °C

3: 84 percent / DCC; HOBt / tetrahydrofuran / 20 °C

4: Pb(OAc)4 / ethyl acetate / 20 °C

5: 100 percent / H₂ / Pd/C / methanol / 6 h / 20 °C / 760.05 Torr

6: 63 percent / K₂CO₃ / acetone / 24 h / Heating

7: 99 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / Heating

8: 96 percent / potassium carbonate / 1 h / 20 °C

9: 73 percent / diisobutylaluminium hydride / CH₂Cl₂; heptane / 1 h / 0 °C

10: 91 percent / aq. HCl / tetrahydrofuran / 48 h / 20 °C

With chromium(VI) oxide; lead(IV) acetate; hydrogenchloride; dmap; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; ethyl acetate; acetone; 4: Diels-Alder reaction;
DOI:10.1021/ja010221k