2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

Base Information

Chemical Name:2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid
CAS No.:1101138-55-9
Molecular Formula:C₂₄H₁₈N₄O₃
Molecular Weight:410.432
Hs Code.:

Synonyms:2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

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Chemical Property of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

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Technology Process of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

There total 4 articles about 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1101137-85-2
ethyl 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzoate

: 1101138-55-9
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

Guidance literature:: ethyl 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzoate; With water; sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 6h;

In water; pH=7;

Reference yield:

: 1101145-49-6
(2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

: 269409-99-6
ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate

: 1101138-55-9
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

Guidance literature:: (2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone; ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate; With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; at 120 ℃; for 0.5h; Inert atmosphere;

With water; sodium hydroxide; at 25 ℃; for 12h;

Reference yield:

: 269409-99-6
ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate

: 1101138-55-9
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water / 120 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 6 h / 80 °C

2.2: pH 7

With water; potassium carbonate; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water;