N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline

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Chemical Name:N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline
CAS No.:1364953-63-8
Molecular Formula:C₂₅H₁₇ClF₂N₂O
Molecular Weight:434.873
Hs Code.:

Synonyms:N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline

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Chemical Property of N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline

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Technology Process of N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline

There total 2 articles about N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1364952-90-8
N-(2-bromo-1-(2-(4-chlorophenyl)-4-phenyl-1H-pyrrol-1-yl)-2,2-difluoroethylidene)-4-methoxyaniline

: 1364953-63-8
N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline

Guidance literature:: With Wilkinson's catalyst; silver carbonate; In 1,4-dioxane; at 120 ℃; for 8h; Inert atmosphere;
DOI:10.1039/c2cc30207a

Reference yield:

: 2-bromo-2,2-difluoro-N-(4-methoxyphenyl)acetimidoyl chloride

: 1364952-19-1
2-(4-chlorophenyl)-4-phenyl-1H-pyrrole

: 1364953-63-8
N-(8-chloro-6,6-difluoro-2-phenylpyrrolo[2,1-a]isoquinolin-5(6H)-ylidene)-4-methoxyaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1.33 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: Wilkinson's catalyst; silver carbonate / 1,4-dioxane / 8 h / 120 °C / Inert atmosphere

With Wilkinson's catalyst; n-butyllithium; silver carbonate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1039/c2cc30207a