(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

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Chemical Name:(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide
CAS No.:1342803-56-8
Molecular Formula:C₂₉H₃₄F₃N₃O₂S
Molecular Weight:545.669
Hs Code.:

Synonyms:(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

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Chemical Property of (S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

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Technology Process of (S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

There total 14 articles about (S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1342804-07-2
(3R,4R)-benzyl 3-(((S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-2-hydroxypropanamido)methyl)-4-fluoropyrrolidine-1-carboxylate

: 1342803-56-8
(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 292858-05-0
ethyl 3-bromo-2-oxo-4-phenylbutanoate

: 1342803-56-8
(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol / Reflux

1.2: 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

4.1: pentane; tetrahydrofuran / 3 h / -78 °C

4.2: -78 °C

4.3: -78 °C

5.1: hydrogenchloride; methanol / 1,4-dioxane; tetrahydrofuran / 1 h / 20 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

8.1: lithium hydroxide; methanol / 0.5 h / 20 °C

9.1: hydrogen / palladium on activated charcoal / ethanol / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; pentane;

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 1342803-56-8
(S)-N-((R)-1-(5-benzyl-2-(2,5-difluorophenyl)thiazol-4-yl)-2,2-dimethylpropyl)-N-(((3S,4R)-4-fluoropyrrolidin-3-yl)methyl)-2-hydroxypropanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: copper(ll) bromide / ethyl acetate; chloroform / 6 h / Reflux

2.1: methanol / Reflux

2.2: 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h / 20 °C

5.1: pentane; tetrahydrofuran / 3 h / -78 °C

5.2: -78 °C

5.3: -78 °C

6.1: hydrogenchloride; methanol / 1,4-dioxane; tetrahydrofuran / 1 h / 20 °C

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

9.1: lithium hydroxide; methanol / 0.5 h / 20 °C

10.1: hydrogen / palladium on activated charcoal / ethanol / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; ethyl acetate; pentane;