N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide
CAS No.:1228465-67-5
Molecular Formula:C₂₄H₁₈F₄N₆O₂S
Molecular Weight:530.506
Hs Code.:

Synonyms:N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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Chemical Property of N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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Technology Process of N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

There total 8 articles about N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1125632-90-7
N-{5-[(3-amino-4-fluorophenyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 1228465-67-5
N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 369-36-8
6-fluoro-3-nitroaniline

: 1228465-67-5
N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 55 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 0.58 h / 90 °C / Inert atmosphere; Microwave irradiation

4: hydrogenchloride / ethyl acetate; water / 0 °C

5: tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; potassium tert-butylate; hydrogen; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; tert-butyl alcohol;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 1228465-67-5
N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 12 h / 85 °C / Cooling

2: tetrahydrofuran / 2 h / 0 °C

3: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 0.58 h / 90 °C / Inert atmosphere; Microwave irradiation

4: hydrogenchloride / ethyl acetate; water / 0 °C

5: tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; potassium tert-butylate; bromine; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; water; ethyl acetate; tert-butyl alcohol;