4-(Aminomethyl)-1-methylpiperidin-4-ol

Base Information

• Chemical Name: 4-(Aminomethyl)-1-methylpiperidin-4-ol
• CAS No.: 26228-68-2
• Molecular Formula: C7H16N2O
• Molecular Weight: 144.217
• Hs Code.: 2933399090
• European Community (EC) Number: 831-934-4
• DSSTox Substance ID: DTXSID20424441
• Wikidata: Q72439688
• Mol file: 26228-68-2.mol

Synonyms:4-(aminomethyl)-1-methylpiperidin-4-ol;26228-68-2;4-Aminomethyl-1-methyl-piperidin-4-ol;4-aminomethyl-4-hydroxy-1-methylpiperidine;4-Aminomethyl-1-methylpiperidin-4-ol;SCHEMBL103283;DTXSID20424441;JUHFGHWNBYGKCW-UHFFFAOYSA-N;MFCD08144105;AKOS000506086;4(aminomethyl)-1-methyl-4-piperidinol;AC-3554;PB14543;N-(Aminomethyl)-1-methylpiperidin-4-ol;AS-50547;A5211;AM20090322;BB 0253629;CS-0051188;FT-0692326;EN300-82619;P10553;4-(Aminomethyl)-1-methyl-4-piperidinol, AldrichCPR;F2189-0871;Z419084820

Chemical Property of 4-(Aminomethyl)-1-methylpiperidin-4-ol

Chemical Property:

• Vapor Pressure: 0.00243mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 255.691 °C at 760 mmHg
• Flash Point: 108.439 °C
• PSA: 49.49000
• Density: 1.048 g/cm³
• LogP: 0.04000
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 144.126263138
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

4-(aminomethyl)-1-methylpiperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(CC1)(CN)O

Technology Process of 4-(Aminomethyl)-1-methylpiperidin-4-ol

There total 5 articles about 4-(Aminomethyl)-1-methylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-methyl-4-(nitromethyl)piperidin-4-ol (116250-49-8) → 4-aminomethyl-4-hydroxy-1-methylpiperidine (26228-68-2)

Guidance literature:

With hydrogen; In methanol; for 16h; under 760.051 Torr;

Reference yield: 74.0%

4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (392331-66-7) → 4-aminomethyl-4-hydroxy-1-methylpiperidine (26228-68-2)

Guidance literature:

4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 5 ℃; Heating;

With rochelle salt; In tetrahydrofuran; at 20 ℃; for 8h;

Reference yield: 47.0%

4-Cyano-4-trimethylsilyloxy-1-methyl-piperidine (150358-78-4) → 4-aminomethyl-4-hydroxy-1-methylpiperidine (26228-68-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

upstream raw materials:

1-methyl-4-(nitromethyl)piperidin-4-ol

4-aminomethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

1-Methyl-4-piperidone

4-Cyano-4-trimethylsilyloxy-1-methyl-piperidine

Downstream raw materials:

8-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

4-acetamidomethyl-4-hydroxy-1-methylpiperidine

1-methyl-4-[({5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}amino)methyl]piperidin-4-ol

1-methyl-4-(((3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)piperidin-4-ol