2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

Base Information

Chemical Name:2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester
CAS No.:1333398-79-0
Molecular Formula:C₂₇H₂₉N₃O₃
Molecular Weight:443.546
Hs Code.:

Synonyms:2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

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Chemical Property of 2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

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Technology Process of 2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

There total 11 articles about 2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₇N₃O₅

: 1333398-79-0
2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

Guidance literature:: In dichloromethane; at 30 ℃; for 16h; Acidic conditions;
DOI:10.1016/j.bmcl.2013.09.040

Reference yield:

: 1333400-87-5
[2-bromo-4-(pyridin-4-ylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester

: 1333398-79-0
2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

2.1: trialkylamine

2.2: 20 °C

3.1: dichloromethane / 16 h / 30 °C / Acidic conditions

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.09.040

Reference yield:

: 1333400-90-0
2'-(tert-butoxycarbonylamino-methyl)-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid

: 1333398-79-0
2'-aminomethyl-5'-(pyridin-4-ylcarbamoyl)-biphenyl-3-carboxylic acid cyclohexyl methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trialkylamine

1.2: 20 °C

2.1: dichloromethane / 16 h / 30 °C / Acidic conditions

With trialkylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2013.09.040