(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate

Base Information

• Chemical Name: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate
• CAS No.: 117049-09-9
• Molecular Formula: C₂₃H₃₄BrNO₄
• Molecular Weight: 468.431
• Mol file: 117049-09-9.mol

Synonyms:(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate

Chemical Property of (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate

There total 4 articles about (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate (117681-86-4) → (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>bromoacetate (117049-09-9)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; Heating; Irradiation;

DOI:10.1039/c39910000332

Reference yield: 99.0%

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate (117681-86-4) → (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate (117049-08-8,117049-09-9,145280-08-6)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 0.166667h; Heating; Irradiation;

DOI:10.1016/S0040-4020(01)90125-5

Reference yield:

(-)-8-phenylmenthol (65253-04-5) → (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate (117049-08-8,117049-09-9,145280-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / dicyclohexylcarbodiimide, N,N-dimethylaminopyridine

2: 99 percent / N-bromosuccinimide / CCl₄ / 0.17 h / Heating; Irradiation

With dmap; N-Bromosuccinimide; dicyclohexyl-carbodiimide; In tetrachloromethane;

DOI:10.1016/S0040-4020(01)90125-5

upstream raw materials:

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate

BOC-glycine

(-)-8-phenylmenthol

Downstream raw materials:

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>propanoate

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutanoate

(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2S)-2-<(tert-butoxycarbonyl)amino>pent-4-enoate

(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2R)-2-<(tert-butoxycarbonyl)amino>pent-4-enoate