(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

Base Information

Chemical Name:(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol
CAS No.:1307809-82-0
Molecular Formula:C₁₉H₁₄F₃NO₂
Molecular Weight:345.321
Hs Code.:

Synonyms:(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

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Chemical Property of (3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

Chemical Property:

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Technology Process of (3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

There total 6 articles about (3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307812-84-5
3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

: 36476-78-5
3-azetidinecarboxylic acid

: 1307809-82-0
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

: 1307809-83-1
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: 3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde; 3-azetidinecarboxylic acid; With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 20 ℃; for 65h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 6h;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307809-82-0
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

: 1307809-83-1
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / toluene / 0.38 h / 0 °C

4.2: 0.52 h / 0 °C

5.1: triethylamine; ozone / dichloromethane / -78 - 20 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / methanol / 65 h / 20 °C

6.2: 6 h / 20 °C

With pyridine; hydroxylamine hydrochloride; sodium acetate; sodium tris(acetoxy)borohydride; ozone; acetic acid; triethylamine; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; toluene;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307809-82-0
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methanol

: 1307809-83-1
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: lithium diisopropyl amide / toluene / 0.38 h / 0 °C

3.2: 0.52 h / 0 °C

4.1: triethylamine; ozone / dichloromethane / -78 - 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / methanol / 65 h / 20 °C

5.2: 6 h / 20 °C

With hydroxylamine hydrochloride; sodium acetate; sodium tris(acetoxy)borohydride; ozone; acetic acid; triethylamine; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; toluene;