(S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

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Chemical Name:(S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate
CAS No.:1621189-30-7
Molecular Formula:C₁₄H₁₉N₂*F₆P
Molecular Weight:360.282
Hs Code.:

Synonyms:(S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

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Chemical Property of (S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

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Technology Process of (S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

There total 5 articles about (S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 122-51-0
orthoformic acid triethyl ester

: 67715-15-5
(S)-1-phenylethyl((S)-pyrrolidin-2-ylmethyl)amine

: 1621189-30-7
(S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

Guidance literature:: With ammonium hexafluorophosphate; at 145 ℃; for 0.0833333h; Microwave irradiation; Inert atmosphere; Schlenk technique;
DOI:10.1055/s-0033-1340215

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1621189-30-7
(S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; chloroformic acid ethyl ester / ethyl acetate / 15 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: 5%-palladium/activated carbon; hydrogen / methanol / 15 h / 20 °C / Inert atmosphere; Schlenk technique

3: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Reflux; Inert atmosphere; Schlenk technique

4: ammonium hexafluorophosphate / 0.08 h / 145 °C / Microwave irradiation; Inert atmosphere; Schlenk technique

With 4-methyl-morpholine; ammonium hexafluorophosphate; lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen; chloroformic acid ethyl ester; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1055/s-0033-1340215

Reference yield:

: 167389-05-1
(2S)-2-((1S)-1-phenylethylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl ester

: 1621189-30-7
(S)-2-[(S)-1-phenylethyl]-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate

Guidance literature:: Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 15 h / 20 °C / Inert atmosphere; Schlenk technique

2: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Reflux; Inert atmosphere; Schlenk technique

3: ammonium hexafluorophosphate / 0.08 h / 145 °C / Microwave irradiation; Inert atmosphere; Schlenk technique

With ammonium hexafluorophosphate; lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1055/s-0033-1340215