(2S)-2-[((2S,5S,7S,8aR)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

Base Information

Chemical Name:(2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester
CAS No.:1131843-87-2
Molecular Formula:C₃₁H₄₄N₂O₇
Molecular Weight:556.7
Hs Code.:

Synonyms:(2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

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Chemical Property of (2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

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Technology Process of (2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

There total 1 articles about (2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (2SR,5SR,7SR,8aRS)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizine-5-carboxylic acid

: 13795-73-8
L-aspartic acid di-tert-butyl ester

: 1131843-87-2
(2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

Guidance literature:: (2SR,5SR,7SR,8aRS)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizine-5-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -10 ℃; for 1h; Inert atmosphere;

L-aspartic acid di-tert-butyl ester; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.tet.2008.12.015

Reference yield: 68.0%

: 1131843-87-2
(2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

: 1131843-89-4
(2S)-2-[((2S*,5S*,7S*,8aR*)-7-benzyloxy-2-(3-hydroxypropyl)-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester

Guidance literature:: (2S)-2-[((2S*,5S*,7S*,8aR*)-2-allyl-7-benzyloxy-3-oxo-octahydroindolizin-5-ylcarbonyl)amino]succinic acid di(tert-butyl) ester; With 9-bora-bicyclo[3.3.1]nonane;

With dihydrogen peroxide; sodium acetate; for 15h;
DOI:10.1016/j.tet.2008.12.015