5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate

Base Information

Chemical Name:5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate
CAS No.:1450020-28-6
Molecular Formula:C₂HF₃O₂*C₂₀H₁₅FN₄OS
Molecular Weight:492.454
Hs Code.:

Synonyms:5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate

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Chemical Property of 5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate

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Technology Process of 5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate

There total 2 articles about 5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188301-91-8
5-(5-bromo-2-(4-fluorophenyl)thiazol-4-yl)-3-methoxypyridin-2-amine

: 1692-15-5
4-pyridylboronic acid

: 76-05-1
trifluoroacetic acid

: 1450020-28-6
5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate

Guidance literature:: 5-(5-bromo-2-(4-fluorophenyl)thiazol-4-yl)-3-methoxypyridin-2-amine; 4-pyridylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 115 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1188301-90-7
5-(2-(4-fluorophenyl)thiazol-4-yl)-3-methoxypyridin-2-amine

: 1450020-28-6
5-(2-(4-fluorophenyl)-5-(pyridin-4-yl)thiazol-4-yl)-3-methoxypyridin-2-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / chloroform / 0 - 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 115 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; In 1,2-dimethoxyethane; chloroform; 2: |Suzuki Coupling;