5-CHLORO-2-(4-METHYLPHENYL)-1H-BENZIMIDAZOLE

Base Information

• Chemical Name: 5-CHLORO-2-(4-METHYLPHENYL)-1H-BENZIMIDAZOLE
• CAS No.: 7118-65-2
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.708
• Mol file: 7118-65-2.mol

Synonyms:6-chloro-2-(4-methylphenyl)-1H-benzimidazole

Chemical Property of 5-CHLORO-2-(4-METHYLPHENYL)-1H-BENZIMIDAZOLE

Chemical Property:

• Melting Point: 223-226 °C
• Boiling Point: 432.4±47.0 °C(Predicted)
• PKA: 9.82±0.10(Predicted)
• Density: 1.286±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

5-CHLORO-2-(4-METHYLPHENYL)-1H-BENZIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-CHLORO-2-(4-METHYLPHENYL)-1H-BENZIMIDAZOLE

There total 14 articles about 5-CHLORO-2-(4-METHYLPHENYL)-1H-BENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-Toluic acid (99-94-5) + 4-Chloro-1,2-phenylenediamine (95-83-0) → 6-chloro-2-(4-methylphenyl)-1H-benzimidazole (7118-65-2)

Guidance literature:

With diphosphorus tetraiodide; In acetonitrile; at 80 ℃; Sealed tube; Inert atmosphere;

DOI:10.14233/ajchem.2018.21001

Reference yield: 91.0%

4-methyl-benzoyl chloride (874-60-2) + 4-Chloro-1,2-phenylenediamine (95-83-0) → 6-chloro-2-(4-methylphenyl)-1H-benzimidazole (7118-65-2)

Guidance literature:

4-methyl-benzoyl chloride; 4-Chloro-1,2-phenylenediamine; In dichloromethane; at 0 - 20 ℃; for 0.416667h;

With MCM-41; In dichloromethane; for 2h; Reflux;

DOI:10.1002/jccs.200800166

Reference yield: 88.0%

4-methyl-benzaldehyde (104-87-0) + 4-Chloro-1,2-phenylenediamine (95-83-0) → 5-chloro-2-(p-tolyl)-1H-benzo[d]imidazole (7118-65-2)

Guidance literature:

With L-carnitine; In ethanol; at 60 ℃; for 0.583333h;

DOI:10.2174/1386207321666181018163940

upstream raw materials:

4-methyl-benzaldehyde

4-Chloro-1,2-phenylenediamine

1-[Chlor(4-methylphenyl)methyl]pyridinium-chlorid

3-(4-methylphenyl)isoxazol-5(4H)-one

Refernces

• 1、 Zhang, Min,Huang, Guoling,Zhang, Xuefang,Lin, Zhenyuan,Li, Yibiao,Li, Bin,Chen, Lu. "Inexpensive weight-reducing aid (L-carnitine) as an efficient catalyst for synthesis of benzimidazoles". . p. 567 - 570. Retrieved 2019/01/14.
• 2、 -. "Method for catalytically synthesizing benzimidazole compound in water phase under microwave radiation". Paragraph 0074. . Retrieved 2017/07/19.