tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate

Base Information

• Chemical Name: tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate
• CAS No.: 1151513-15-3
• Molecular Formula: C₂₄H₂₆N₆O₄
• Molecular Weight: 462.508

Synonyms:tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate

Chemical Property of tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate

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Technology Process of tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate

There total 1 articles about tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-[3-tert-butoxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl]indazole (1151512-98-9) → tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate (1151513-15-3)

Guidance literature:

3-[3-tert-butoxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl]indazole; With caesium carbonate; In N,N-dimethyl-formamide; for 0.5h;

4-acetamidobenzyl halide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm801180p

Reference yield: 82.0%

tert-butyl (5-(1-(4-acetamidobenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate (1151513-15-3) → N-(4-((3-(3-(aminomethyl)-1,2,4-oxadiazol-5-yl)-1H-indazol-1-yl)methyl)phenyl)acetamide (1151513-39-1)

Guidance literature:

With chlorotriisopropylsilane; trifluoroacetic acid; In water; at 20 ℃; for 18h;

DOI:10.1021/jm801180p

upstream raw materials:

3-[3-tert-butoxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl]indazole

Downstream raw materials:

N-(4-((3-(3-(aminomethyl)-1,2,4-oxadiazol-5-yl)-1H-indazol-1-yl)methyl)phenyl)acetamide

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