(1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide
CAS No.:1293981-59-5
Molecular Formula:C₂₉H₄₁NO₄Si
Molecular Weight:495.734
Hs Code.:

Synonyms:(1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

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Chemical Property of (1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

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Technology Process of (1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

There total 6 articles about (1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₅H₁₀BrNO

: 1293981-33-5
9-(tert-butyldiphenylsilyloxy)non-1-en-3-one

: 1293981-59-5
(1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

Guidance literature:: With C₂₇H₃₀N₂O₂; caesium carbonate; In acetonitrile; at 80 ℃; for 24h; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.02.008

Reference yield:

: 1293981-48-2
9-(tert-butyldiphenylsilyloxy)non-1-en-3-ol

: 1293981-59-5
(1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2-iodoxybenzoic acid / tetrahydrofuran; dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

2: C₂₇H₃₀N₂O₂; caesium carbonate / acetonitrile / 24 h / 80 °C / Inert atmosphere

With 2-iodoxybenzoic acid; C₂₇H₃₀N₂O₂; caesium carbonate; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tetlet.2011.02.008

Reference yield:

: 629-30-1
1,7-heptandiol

: 1293981-59-5
(1S,2S)-2-(7-(tert-butyldiphenylsilyloxy)heptanoyl)-N-methoxy-N-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; oil / 0 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 °C / Inert atmosphere

4.1: 2-iodoxybenzoic acid / tetrahydrofuran; dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

5.1: C₂₇H₃₀N₂O₂; caesium carbonate / acetonitrile / 24 h / 80 °C / Inert atmosphere

With 2-iodoxybenzoic acid; C₂₇H₃₀N₂O₂; sodium acetate; sodium hydride; caesium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile; oil;
DOI:10.1016/j.tetlet.2011.02.008