Technology Process of 1-benzyl-3-ethyl-1,2,3,6-tetrahydropyridine
There total 6 articles about 1-benzyl-3-ethyl-1,2,3,6-tetrahydropyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-(1-benzyl-2,5-dihydro-1H-pyrrol-2-yl)methanol;
With
trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -15 ℃;
Inert atmosphere;
ethylmagnesium chloride;
With
copper(l) cyanide;
In
tetrahydrofuran; dichloromethane;
at -15 - 20 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol201349k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
2.1: trifluoromethylsulfonic anhydride / dichloromethane / -15 °C / Inert atmosphere
2.2: -15 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; trifluoromethylsulfonic anhydride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201349k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / ethanol; water / 0.17 h / 20 °C
1.2: 16 h / pH 8 / Reflux
2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 16 h / Inert atmosphere; Reflux
3.1: sodium periodate / ethanol; water / 0.75 h / 20 °C / Cooling with ice
3.2: 16 h / 20 °C / Cooling with ice
4.1: trifluoromethylsulfonic anhydride / dichloromethane / -15 °C / Inert atmosphere
4.2: -15 - 20 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium periodate; trifluoromethylsulfonic anhydride; sulfuric acid;
In
ethanol; dichloromethane; water;
DOI:10.1021/ol201349k
