N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine

Base Information

• Chemical Name: N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine
• CAS No.: 63648-87-3
• Molecular Formula: C₂₀H₂₆N₄O₅
• Molecular Weight: 402.45
• Mol file: 63648-87-3.mol

Synonyms:N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine

Chemical Property of N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine

There total 1 articles about N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine (63648-87-3)

Guidance literature:

Reference yield: 72.0%

(2R,4S,5S)-5-Amino-2-azidomethyl-6-cyclohexyl-2,4-dihydroxy-hexanoic acid isobutyl-amide; hydrochloride + N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine (63648-87-3) → N--L-phenylalanyl-L-histidyl>-5(S)-amino-1-azido-6-cyclohexyl-2(R),4(S)-dihydroxy-2-(isobutylcarbamoyl)hexane

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -23 - 20 ℃;

DOI:10.1021/jm00394a008

Reference yield: 63.0%

(2S,3S)-2-Amino-1-cyclohexyl-6-methyl-heptan-3-ol; hydrochloride + N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidine (63648-87-3) → {(S)-1-[(S)-1-((1S,2S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; -23 deg C -> room temperature, 3 h; room temperature, 18 h;

DOI:10.1021/jm00120a005

Downstream raw materials:

{(2R,3S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-2-hydroxy-5-methyl-hexyl}-phosphonic acid dimethyl ester

{(S)-1-[1-[(S)-1-Cyclohexylmethyl-3-(dimethyl-phosphinoyl)-2-hydroxy-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

{(S)-1-[(S)-1-((1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-isobutylcarbamoyl-pent-4-enylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

{(2R,3S)-3-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid diethyl ester